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He comes from Sowutuom, a suburb in Accra, Ghana. Medikal and Sarkodie had the highest nominations for the 2017 edition of the Ghana Music Awards. In 2018, he was on the Tim Westwood Show. Medikal had his High School education at Odorgonno Senior High. He is the son of James Frimpong and Portia Lamptey. Samuel adopted the name Medikal because he was fascinated with rapping about doctors, surgeons, medical practitioners, and hospitals in general. He has made a name for himself in the music industry through hard work and numerous collaborations with successful artists. Apart from his nominations in 2017, he won the best discovery video in the MTN 4Syte Video Award in 2016.